Abstract #0579

DCE-MRI is more sensitive than IVIM-DWI for assessing therapy induced changes in tumour perfusion in colorectal liver metastases

Mihaela Rata¹, Khurum Khan², David Collins¹, Dow-Mu Koh¹, Nina Tunariu¹, Maria Antonietta Bali¹, James d'Arcy¹, Simona Picchia¹, Ian Chau², Nicola Valeri², David Cunningham², Martin O Leach¹, and Matthew R Orton¹

¹CRUK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom, ²Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom

This study evaluates response to anti-angiogenic treatment in 25 patients with colorectal liver metastases to determine whether the observed changes on dynamic contrast enhanced (DCE)-MRI are detectable by IVIM-DWI. Significant therapy response measured in this cohort by DCE and confirmed by tumour biopsies was not mirrored by the perfusion related IVIM parameters. No strong correlation was found between DCE and IVIM perfusion parameters. DCE-MRI is more sensitive than IVIM-DWI for assessing therapy induced changes in tumour perfusion in colorectal liver metastases.

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