Imaging injectable liposomal hydrogels using CEST MRI for applications in the brain
Xiongqi Han1, Jianpan Huang1, Peng Xiao1, Joseph Ho Chi Lai1, and Kannie Wai Yan Chan1,2,3
1City University of Hong Kong, Hong Kong, China, 2Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
Nanocarrier-loaded hydrogel shows good prospects in biomedical application. However, there is lack of noninvasive methods for real time monitoring to guide therapy. Here, we developed a CEST-nanosensor incorporated injectable hydrogel using two most commonly used hydrogel (alginate, and hyaluronan-methylcellulose (HAMC)) and liposomes. Both hydrogels showed storage modulus (G’) comparable to native brain tissue and good injectabilities. Moreover, we observed that our LipoCEST hydrogels generate unique CEST contrasts at 5 ppm (barbituric acid (BA), drug) and -3.4 ppm (liposomes) on 3T, facilitating the multicolor CEST imaging and imaging-guided therapy in brain applications.
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