Abstract #0538

Hyperoxia calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain Yv: Comparison to standard calibration models and measurement of CMRO2 response to finger tapping

Erin K Englund¹, Maria A Fernandez-Seara², Ana E Rodriguez-Soto¹, Hyunyeol Lee¹, John A Detre³, Zachary B Rodgers¹, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Navarra, Pamplona, Spain, ³Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

The magnitude of neurometabolic responses to stimuli can be quantified using calibrated fMRI. Here we compare existing calibration models to Y_v-based calibration. The Y_v-based calibration model measures whole-brain venous oxygen saturation in the superior sagittal sinus along with BOLD changes and ASL-measured CBF changes to derive maps of the calibration constant, M, in response to a hyperoxia stimulus. M-maps were compared between the proposed and existing calibration models. Then, relative CMRO₂ changes in response to a finger tapping task were computed based on the derived M-maps. A ~19% increase in CMRO₂ in the motor cortex was observed.

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