Abstract #0536

Testing temporal dependence of spatial specificity in BOLD fMRI at 7T: comparing short versus long stimulus duration

Anna I Blazejewska^1,2, Michael I Bernier^1,2, Shahin I Nasr^1,2, and Jonathan R Polimeni^1,2,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ³Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

The spatial specificity of the BOLD-fMRI response has previously been shown to vary systematically across cortical depths, with highest specificity found in voxels furthest from the pial surface, while highest sensitivity of the response is found in voxels closest to the pial vessels. Analogous trade-offs between spatial specificity and sensitivity can be appreciated in the temporal evolution of the BOLD-fMRI response. Here we investigate spatial specificity of the response to both short-duration and long-duration stimuli as they evolve in time using high-resolution BOLD-fMRI at 7T, and demonstrate that BOLD-fMRI response exhibits high specificity both at early and late time points.

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