Abstract #0526

Spine atrophy and sensory-motor disability in African Americans with Multiple Sclerosis

Mohamed Mounir El Mendili¹, Maria Petracca¹, Amgad Droby¹, Giacomo Boffa², Swetha Paduri³, Christopher Langston³, Ilena George³, Claire Riley⁴, Jonathan Howard⁵, Sylvia Klineova⁶, and Matilde Inglese^2,7

¹Neurology, Department of Neurology, Icahn School of Medicine at Mount Sinai, NEW YORK, NY, United States, ²Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health, University of Genoa, Genoa, Italy, ³Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Neurology, Columbia University Medical Center, New York, NY, United States, ⁵Department of Neurology, New York University School of Medicine, New York, NY, United States, ⁶Department of Neurology, Icahn School of Medicine, New York, NY, United States, ⁷Department of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

African Americans with multiple sclerosis (MS) present a more severe disease course than Caucasians with MS, but the contribution of spinal lesions and cervical spinal cord damage to clinical disability has never been explored.

In the present study, we investigated the extent of cervical spinal cord (CSC) damage in AA MS patients compared to age-, sex- and race matched healthy controls. Our study showed that CSC damage in terms of both macroscopic lesions and atrophy significantly impacts motor and sensory performances in AA with MS.

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