Abstract #0491

Glycogen detection in human brain via natural abundance 13C MRS at 7T

Sergey Cheshkov^1,2, Ivan E. Dimitrov^1,3, Brandy Verhalen⁴, A. Dean Sherry^1,2,5, Berge Minassian⁴, and Craig R. Malloy^1,2,6

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Philips Healthcare, Gainesville, FL, United States, ⁴Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Chemistry, University of Texas at Dallas, Dallas, TX, United States, ⁶Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

Large quantities of abnormally-branched brain glycogen are hypothesized to be accumulating in disorders such as Lafora disease and Adult Polyglucosan Body Disease (APBD). However, non-invasive tools for brain glycogen detection in vivo are lacking. In this work we have used natural abundance ¹³C MRS at 7T with NOE, to detect glycogen in both normal and APBD brain. Qualitative comparison of the respective glycogen C1 signals in these two cases indicates no dramatic increase of the detectable glycogen concentration in APBD. To our knowledge this is the first human cerebral glycogen detection via natural abundance ¹³C MRS.

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