Abstract #0463

Quantitative Measurements of Carotid Atherosclerotic Plaque Compositions using in vivo T1 Mapping: Validation by Histology

Huiyu Qiao¹, Dongye Li¹, Hualu Han¹, Yongjun Han¹, Jingli Cao^2,3, Haikun Qi⁴, Huijun Chen¹, Tao Wang⁵, Huimin Xu⁶, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, ²Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³China National Clinical Research Center for Neurological Diseases, Beijing, China, ⁴School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁵Department of Neurosurgery, Peking University Third Hospital, Beijing, China, ⁶Department of Radiology, Peking University Third Hospital, Beijing, China

Plaque compositional features are effective indicators for vulnerability and associated with ischemic stroke risk. Multicontrast vessel wall imaging has been utilized to characterize plaque compositions but this technique is time consuming and dependent on reviewer’s experience. Therefore, it is important to characterize plaque compositions with time-efficient imaging approach. This study sought to determine T1 values of carotid plaque components determined by quantitative imaging validated by histology. We found that the T1 values of intraplaque hemorrhage, necrotic core, and loose matrix were distinguishable. Our findings suggest that carotid plaque components might be distinguishable and automatically segmented on quantitative MR imaging.

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