Abstract #0414

Simultaneous Measurement of Perfusion and T2* in Calf Muscle at 7T with Dynamic Exercise using Radial Acquisition.

Sultan Zaman Mahmud¹, Bruce Gladden², Andreas Kavazis², Robert Motl³, Thomas Denney¹, and Adil Bashir¹

¹Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ²School of Kinesiology, Auburn University, Auburn, AL, United States, ³Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, United States

Impairments in oxygen delivery and consumption can lead to reduced muscle endurance and physical disability. Perfusion, a measure of microvascular blood flow, provides information on nutrient delivery. T₂* provides information about relative tissue oxygenation. Changes in these parameters following stress, such as exercise, can yield important information about imbalance between delivery and consumption. In this study we implemented golden angle radial MRI acquisition technique to simultaneously quantify muscle perfusion and T₂* at 7T, and demonstrate assessment of spatial and temporal changes in these parameters within calf muscles during recovery from plantar flexion exercise.

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