Quantitative MR techniques have shown promise for detection of muscle micro trauma. Muscle injury and recovery involve many pathophysiological processes including, inflammation, regeneration and fibrosis, therefore multi-parametric approaches are critically needed. This study used a multi-parametric quantitative approach to assess micro structural changes in the upper leg muscles after running a marathon on an individual muscle basis as well as on a localized level. Our results indicate that diffusion indices are highly sensitive to detect micro-structural changes on a localized and whole volume basis and that this approach could prove valuable for improved outcome prediction and risk-assessment of sports-related-injuries.
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