Abstract #0404

Diffusion tensor cardiovascular magnetic resonance in a Langendorff perfused beating porcine heart

Andrew David Scott¹, Timothy Jackson², Zohya Khalique¹, Margarita Gorodezky¹, Ben Pardoe², Domenico Bruno³, Rasheda A Chowdhury⁴, Ferreira F Pedro¹, Sonia Nielles-Vallespin¹, Lale Begum², Malte Roehl¹, Padmini Sarathchandra⁵, Jan N Rose⁶, Denis J Doorly⁶, Dudley J Pennell¹, Raimondo Ascione³, Ranil de Silva¹, and David N Firmin¹

¹Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital and Imperial College London, London, United Kingdom, ²Department of Perfusion, The Royal Brompton Hospital, London, United Kingdom, ³Translational Biomedical Research Centre, University of Bristol, Bristol, United Kingdom, ⁴National Heart and Lung Institute, Imperial College London, London, United Kingdom, ⁵Magdi Yacoub Institute, Imperial College London, London, United Kingdom, ⁶Aeronautics, Imperial College London, London, United Kingdom

We have developed an MRI compatible Langendorff perfused beating isolated porcine heart model. Hearts are harvested and transported to a remote imaging centre, avoiding the need for onsite pre-clinical facilities. The model allows comparison of beating and arrested data in equivalent cardiac states. We performed cine imaging, parametric mapping and diffusion tensor cardiovascular magnetic resonance in the beating and arrested hearts. After MRI, co-localised 3D histology is performed.

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