Abstract #0395

Evaluation of Fractional Tumor Burden (FTB) fidelity using a no-preload, low-flip angle dynamic susceptibility contrast MRI acquisition scheme

Melissa A Prah¹, Leland S Hu², Jerrold L Boxerman³, C. Chad Quarles⁴, Jennifer M Connelly⁵, and Kathleen M Schmainda^1,6

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States, ³Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States, ⁴Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ⁵Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Radiology, Medical College of Wisconsin, Milwaukee, WI, United States

This study examines the fidelity of a no pre-load, low flip-angle (LFA) dynamic susceptibility contrast MRI acquisition approach in the calculation of Fractional Tumor Burden (FTB) maps, which have shown promise as a predictive biomarker in glioblastoma patients. The LFA approach was recently identified as providing similar accuracy to the standard mid-range flip-angle approach with preload. FTB was found to have robust quantitative and spatial agreement between LFA and MFA approaches. The results of this study bode well for increased adoption of FTB as a biomarker amenable to both the standard and newer LFA approach.

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