Abstract #0349

Gyri and sulci microstructural differences in the sheep brain during cortical folding assessed by diffusion MRI.

Yohan van de Looij^1,2, Sebastian Quezada³, David Walker⁴, Nadia Hale³, Mary Tolcos⁴, Petra S Hüppi¹, and Stéphane V Sizonenko¹

¹Service développement et croissance, Université de Genève, Genève, Switzerland, ²Laboratoire d'imagerie fonctionnelle et métabolique, Ecole polytechnique fédérale de Lausanne, Lausanne, Switzerland, ³The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, Australia, ⁴School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia

Despite a large number of studies assessing cerebral development, some of the events underlying folding of the cerebral cortex remain unclear, especially those concerning micro-architectural differences between outward (gyri) and inward (sulci) folds. The aim of this work was twofold: 1) depict cortical microstructure differences between gyri and sulci and 2) assess the potential of NODDI in the understanding of cortical folding. Gyri and sulci present different maturation timelines leading to microstructural differences. Diffusion imaging is a powerful tool to probe accurately these differences. These results are of high interest for the understanding of cortical folding process.

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