Abstract #0340

Age-specific Quantitative Brain Atlas Modelling Brain Shape and T1 Changes

Tom Hilbert^1,2,3, Gian-Franco Piredda^1,2,3, Karl Egger⁴, Shan Yang⁴, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Department of Neuroradiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

In order to facilitate the use of quantitative mapping approaches in clinical routine, atlases with normative quantitative values are required for comparison on a single-subject basis. To improve such comparison, we propose here to not only model the age-related change in T1, but also the change in brain shape. The method is demonstrated on a dataset of 196 quantitative T1 maps, yielding a brain model with shape and T1 information over the potential lifespan of a patient to assess.

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