Abstract #0336

Hippocampal NAA/mIns ratio and spatial working memory across the lifespan

Anna Lind¹, Carl-Johan Boraxbekk¹, Hartwig Roman Siebner^1,2,3, Esben Thade Petersen^1,4, and Anouk Marsman¹

¹Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ²Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, ³Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ⁴Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark

The NAA/mIns ratio has been proposed as a marker of unhealthy ageing. We found that the NAA/mIns ratio is decreased in the hippocampus for middle-aged and old individuals compared to young individuals. For old individuals, declining NAA/mIns ratios are correlated with poorer performance on a spatial working memory task but this relationship is not found in middle-aged and young individuals. Our results suggest that the NAA/mIns ratio decrease in the hippocampus is observable before the negative functional effects.

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