Abstract #0312

T2-gSlider: rapid high resolution T2 mapping with generalized SLIce Dithered Enhanced Resolution and model-based reconstruction

Xiaozhi Cao¹, Congyu Liao^2,3, Siddharth Srinivasan Iyer^3,4, Hongjian He¹, Kawin Setsompop^2,3, Jianhui Zhong^1,5, and Berkin Bilgic^2,3

¹Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, ²Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

To obtain rapid high isotropic resolution whole-brain T₂ maps, a T₂ generalized Slice-dithered enhanced resolution (T₂-gSlider) acquisition/reconstruction framework is proposed. An accelerated RF-encoded multi-slab, multi-shot SE-EPI acquisition with variable TEs was developed to obtain high SNR acquisitions with reduced TR. A structured low-rank constraint was applied to reconstruct highly undersampled multi-shot data and achieve robust reconstruction for each slab. A Bloch simulated subspace shuffling model was utilized for T₂ quantification and incorporated into gSlider reconstruction to further accelerate the acquisition. The proposed framework is demonstrated to enable whole-brain 1mm isotropic T₂ mapping in ~40 seconds.

This abstract and the presentation materials are available to members only; a login is required.

Join Here