Abstract #0309

Magnetization transfer (MT) of human brain at 7T in the context of a 3D multi-parameter mapping protocol

Hampus Olsson¹, Mads Andersen^2,3, Jimmy Lätt^4,5, Ronnie Wirestam¹, and Gunther Helms^1,3

¹Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, ²Philips Danmark A/S, Philips Healthcare, Copenhagen, Denmark, ³National 7T Facility, Lund University, Lund, Sweden, ⁴Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, ⁵Clinical Sciences Lund, Department of Radiology, Lund University, Lund, Sweden

3D multi-gradient echo MRI can be used to estimate T₁, T₂*, PD and the magnetization transfer (MT), which is increasingly used for multi-parametric mapping (MPM) of human brain. The increased polarization at 7T compared to lower B₀ allows for increased spatial resolution or reduced scan times. However, SAR restrictions imposed on the MT pulse and B₁ inhomogeneity pose challenges. In this work, we propose a protocol for MPM of human brain at 7T with special attention paid to eliminating bias when mapping MT_sat while obtaining submillimeter isotropic spatial resolution in under 12 minutes with acceptable SNR.

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