Abstract #0297

Investigating tissue microstructure using NODDI and histology: A chronic injury study on ex vivo macaque spinal cords

Andrew Bauman^1,2, Andrew Yung^1,2, Jie Liu³, Junhao Liu⁴, Qingan Zhu⁴, Piotr Kozlowski^1,2,3, and Wolfram Tetzlaff³

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

In this study we sought to understand whether Neurite Orientation Dispersion and Density Imaging (NODDI) could accurately delineate the extent of microstructure damage in an ex-vivo macaque spinal cord. We used histology as a gold standard for delineating the margin between damaged and undamaged tissue. Qualitative analysis exposed disagreements between NODDI maps and histology in areas of damage. This suggests that NODDI may not be appropriate for this model of chronic spinal cord injury.

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