Abstract #0289

The Quantification of Feuromxytol Uptake on the Post Enhance in Intracranial Atherosclerotic Plaque by using a 3D high resolution Black Blood(BB) Multiple Echo(ME) T2* Imaging Technique

Seong-Eun Kim¹, J Scott McNally¹, Matthew Alexander¹, Dennis L Parker¹, Bradley D Bolster Jr², Gerald S Treiman^3,4, and Adam de Havenon⁵

¹UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ²Siemens Healthcare, Salt Lake City, UT, United States, ³Department of Surgery, University of Utah, Salt Lake City, UT, United States, ⁴Department of Veterans Affairs, VASLCHCS, Salt Lake City, UT, United States, ⁵Department of Neurology, University of Utah, Salt Lake City, UT, United States

Post-gadoliniun enhancement(PGE) in ICAD may be related to endothelial dysfunction or breakdown or secondary to plaque inflammation. Delayed ferumoxytol imaging allows intravascular clearance with retention in the macrophages present in vulnerable atherosclerotic plaque. A 3D BB ME T2* Imaging technique allows the quantitative ferumoxytol imaging on delayed scans by measuring T2* in intracranial atherosclerotic plaque. We performed 3D BB T2* sequences on ten patients with ICAD and measured T2* changes between baseline and 72 hour after ferumoxytol injection. The iron nanoparticle uptake in symptomatic ICAD presented in this work may provide important mechanistic implications for the pathophysiology of PGE.

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