Abstract #0248

Reduced Regional Cerebral Venous Oxygen Saturation is a Risk Factor for Cognitive Impairment in Hemodialysis Patients: A Susceptibility-weighted Image Mapping Study

Chao Chai¹, Huiying Wang¹, Jinping Li², Jinxia Zhu³, Xianchang Zhang³, E. Mark Haacke⁴, Shuang Xia¹, and Wen Shen¹

¹Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ²Deparment of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, ³MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ⁴Department of Radiology, Wayne State University, Detroit, MI, United States

The purpose of this study was to noninvasively evaluate the changes of regional cerebral venous oxygen saturation (rSvO₂) in hemodialysis patients using quantitative susceptibility-weighted image mapping (SWIM) and then to investigate the relationship between rSvO₂, clinical risk factors, and neuropsychological testing results. The results suggest that cerebral rSvO₂ is reduced in hemodialysis patients and that this reduction may correlate with neurocognitive dysfunction. Hematocrit, iron, glucose, and pre- and post-dialysis DBP were independent risk factors for reduced cerebral rSvO₂.

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