Abstract #0206

Simultaneous fMRE and fMRI measures the viscoelastic and BOLD responses of the human brain to functional activation in the visual cortex

Patricia S. Lan¹, Kevin J. Glaser², Richard L. Ehman², and Gary H. Glover³

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Radiology, Mayo Clinic, Rochester, MN, United States, ³Radiology, Stanford University, Stanford, CA, United States

Here, we demonstrate a novel multi-modal method to simultaneously acquire robust fMRE and fMRI activation maps. A block paradigm of 24s ON (flashing checkerboard at 10Hz) and 24s OFF (fixation cross) was used and images were acquired with a single-shot spin-echo EPI MRE sequence. Our results show that tissue stiffness within the visual cortex increases 6-12% with visual stimuli. Furthermore, the fMRE and fMRI activation maps agree and overlap spatially within the visual cortex, providing convincing evidence that fMRE is possible in the cortex.

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