This study demonstrated significant increases in flux through glycolysis, oxidative metabolism, and glutaminolysis associated with androgen independence using patient-derived cell lines and a treatment-driven murine model. This data supports using a combination of hyperpolarized [1-13C]pyruvate, [2-13C]pyruvate and [5-13C]glutamine to noninvasively discriminate between androgen-dependent and androgen-independent prostate cancer in future patient studies using hyperpolarized 13C MRI.
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