Abstract #0181

Spiral-MRSI and tissue segmentation of normal-appearing white matter and white matter lesion load in relapsing remitting Multiple Sclerosis.

Oun Al-iedani^1,2, Karen Ribbons ^2,3, Jeannette Lechner-Scott^2,3,4, Scott Quadrelli⁵, Rodney Lea², Ovidiu Andronesi⁶, and Saadallah Ramadan^1,2

¹School of Health Sciences, University of Newcastle, Newcastle, Australia, ²Hunter Medical Research Institute, Newcastle, Australia, ³Department of Neurology, John Hunter Hospital, Newcastle, Australia, ⁴School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, ⁵Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ⁶Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

The study evaluated a novel Fast-MRSI technique with tissue segmentation in determining metabolic alterations in NAWM and WM-lesions in MS compared to healthy controls. 3D-MPRAGE and 3D-Spiral-MRSI covering 70% of total brain on 16 RRMS and 9 HCs (aged 22-55yrs) were used. MRSI was processed using MATLAB and LCModel. Findings revealed that (NAA/tCr) in WM-lesions was significantly lower than NAWM-MS and HCs. Volumetric segmentation using SIENAX, revealed a significant WBV reduction and CSF increase in RRMS compared to HCs. Fast-MRSI may enhance diagnosis and clinical monitoring of MS patients, and is sensitive in diagnosing MS even in NAWM.

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