Abstract #0175

Glial and axonal changes in mouse models of disease investigated with diffusion-weighted magnetic resonance spectroscopy at 11.7 T

Guglielmo Genovese^1,2, Mathieu Santin^1,2, Marco Palombo³, Julien Valette⁴, Clemence Ligneul⁵, Marie-Stéphane Aigrot^2,6, Mehdi Felfli¹, Nasteho Abdoulkader¹, Dominique Langui^2,6, Aymeric Millecamps^2,6, Anne Baron-Van Evercooren², Bruno Stankoff², Stéphane Lehericy^1,2, Alexandra Petiet^1,2, and Francesca Branzoli^1,2

¹Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinère (ICM), Paris, France, ²Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinère (ICM), Paris, France, ³Department of Computer Science and Centre for Medical Image Computing, University College of London (UCL), London, United Kingdom, ⁴Institute of biomedical imaging, Atomic Energy and Alternative Energies Commission (CEA), Fontenay-aux-Roses, France, ⁵Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, ⁶Core Facility ICM.Quant, Institut du Cerveau et de la Moelle épinère (ICM), Paris, France

The goal of this study was to evaluate the alterations of white matter microstructure in two different mouse models of white matter disease: the cuprizone (CPZ) model of multiple sclerosis and the Plp1 overexpressing (PLP-tg⁶⁶) model of Pelizeaus-Merzbacher disease. To this end, we employed diffusion-weighted MR spectroscopy (DW-MRS) to measure concentrations and apparent diffusion coefficients of several metabolites in the corpus callosum of wild-type, CPZ and PLP-tg⁶⁶ mice at 11.7 T. DW-MRS markers of axonal and glial degeneration were compared with histological measures.

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