Identifying true positives from diffusion weighted imaging (DWI)-based tractography is not trivial, and no universal gold standard has yet been developed. In this study, we introduce a method which utilizes the group-level streamline pathway distribution to determine inter-subject reproducibility of streamline bundles. At the participant level, streamlines that do not correspond to reproducible bundles are removed, resulting in improved reproducibility and increased fidelity when identifying differences between pathways. Additionally, we utilized electrical stimulation-based cortico-cortical evoked potentials to assess how well reliable bundles reflect underlying connectivity. Cleaned structural connectivity data was found to better correlate with electrophysiological connectivity.
This abstract and the presentation materials are available to members only; a login is required.