Abstract #0169

Mapping short association fibres in the human visual system with ultra high resolution and high sensitivity diffusion MRI

Fakhereh Movahedian Attar^1,2, Evgeniya Kirilina^1,3, Daniel Hänelt^1,2, Luke J Edwards¹, Kerrin J Pine¹, and Nikolaus Weiskopf^1,4

¹Neurophysics, Max Planck Institute for Human cognitive and Brain Sciences, Leipzig, Germany, ²International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, Leipzig, Germany, ³Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Free University Berlin, Berlin, Germany, ⁴Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany

Short association fibres connect proximal cortical areas over short distances. These fibres are highly underrepresented in the current MRI-derived human brain connectome. We combined sub-millimetre resolution diffusion MRI, acquired with a 300 mT/m gradient system and high sensitivity coil for imaging the occipital cortex, with fMRI-driven retinotopic maps of V1/V2. These maps were used to identify the short V1-V2 connections in the human visual processing stream. V1-V2 connectivity was in agreement with previously reported anatomical and functional connectivities. Our results provide an important step towards the construction of a more complete MRI-derived human brain connectome via robust short fibre mapping.

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