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Abstract #0166

On the intrahemispheric connectivity of the monkey: a diffusion tractography and tract tracing analysis

Gabriel Girard1,2, Roberto Caminiti3,4, Alexandra Battaglia-Mayer3, Etienne St-Onge5, Karen S. Ambrosen6,7, Simon F. Eskildsen8, Kristine Krug9, Tim B. Dyrby7,10, Maxime Descoteaux5, Giorgio Innocenti11,12, and Jean-Philippe Thiran1,2

1Radiology Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, 2Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Department of Physiology and Pharmacology, University of Rome SAPIENZA, Rome, Italy, 4Department of Anatomy, Histology, Forensic Medicine, and Orthopedics, University of Rome SAPIENZA, Rome, Italy, 5Sherbrooke Connectivity Imaging Lab, Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada, 6Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 7Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 8Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 9Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 10Department of Applied Mathematics an Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 11Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, 12Brain and Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

In this work, we compare diffusion tractography with neuronal retrograde tract tracing of the frontal, cingulate and parietal areas of the monkey. We analyze the agreements between the tractography and the tracing for connected and not connected regions. We report an accuracy of 0.71 across all pairs of regions, with twice the number of true positive than false positive connections. Some regions show accuracy higher than 0.80, while other regions show accuracy lower than 0.6. A further analysis of the location of false positive and false negative connections will help understand the limitations and improve diffusion tractography algorithms.

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