Abstract #0107

5-Minute Double-Echo in Steady-State with Separated Echoes for Comprehensive Whole-Joint Knee MRI Assessment with and without a Proton-Density-Weighted Sequence

Akshay Chaudhari^1,2, Zhongnan Fang³, Murray Grissom¹, Bragi Sveinsson^4,5, Jeff P. Wood¹, Christopher F. Beaulieu^1,6, Edwin H. G. Oei⁷, Jarrett K. Rosenberg¹, Feliks Kogan¹, Jin Hyung Lee^2,8,9,10, Marcus T. Alley¹, Garry E. Gold^1,2,6, Kathryn J. Stevens^1,6, and Brian A. Hargreaves^1,2,8

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Bioengineering, Stanford University, Stanford, CA, United States, ³LVIS Corporation, Palo Alto, CA, United States, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁶Department of Orthopaedic Surgery, Stanford University, Stanford, CA, United States, ⁷Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁸Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ⁹Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States, ¹⁰Department of Neurology, Stanford University, Stanford, CA, United States

Most knee MRI protocols require 20+ minutes of scan time, leading to interest in expedited protocols. Here, we first demonstrate in a study with 35 patients and 5 readers that for diagnostic knee MRI, a 3D 5-minute quantitative double-echo steady-state (qDESS) sequence has high agreement with the conventional sequences, where the addition of a proton-density-weighted sequence engenders near-perfect agreement. In a second study with 51 patients and 2 readers, we demonstrate that qDESS with two-fold enhanced slice resolution using deep-learning-based super-resolution and T2 maps has high agreement with the conventional sequences, where both methods have similar agreement with arthroscopic findings.

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