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Abstract #0102

The feasibility of matching  lymph nodes detected on USPIO-enhanced MRI with histopathology in rectal cancer

Rutger C.H. Stijns1, Bart W.J. Philips1, Iris D. Nagtegaal2, Fatih Polat3, Johannes H.W. de Wilt4, Carla A.P. Wauters5, Patrik H.W. Zamecnik6, Jurgen J. Futterer1, and Tom W.J. Scheenen1

1Radiology, Radboudumc, Nijmegen, Netherlands, 2Pathology, Radboudumc, Nijmegen, Netherlands, 3Surgery, Cansius-Wilhelmina hospital, Nijmegen, Netherlands, 4Surgery, Radboudumc, Nijmegen, Netherlands, 5Pathology, Cansius-Wilhelmina hospital, Nijmegen, Netherlands, 6Radboudumc, Nijmegen, Netherlands

Lymph node staging in rectal cancer based on imaging is a major challenge. Node-to-node matching is crucial to determine the histopathology of lymph nodes that are detected on in-vivo MRI. A workflow of in-vivo MRI, ex-vivo MRI and MR-guided pathology was set up for lymph nodes that were characterized on USPIO-enhanced MRI. Difficulties were seen in the node-to-node matching, in despite of the use of high-resolution 3D ex-vivo MRI to link in-vivo detected nodes to final pathology.

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