As the prevalence of diffusion MRI for clinical use grows, it is important to address the influence of injury-related extracellular water on the clinical interpretation of diffusion measures in conditions such as traumatic brain injury (TBI). The presence of extracellular free water from edema pollutes the estimation of diffusion measures, leading to flawed conclusions about the microstructure of the white matter. We demonstrate that Fernet, a robust single-shell free-water elimination method, can be used to decouple the effects of extracellular edema and tissue damage, to improve clinical understanding of the effects of injury on underlying white matter structure.
This abstract and the presentation materials are available to members only; a login is required.