Diffusion weighted MRI using oscillating gradients has previously been shown to provide microstructural information on celllularity in tumors, which may serve as marker for monitoring therapy response. Which geometrical model for analysis of such data provides most reliable results, is, however, a matter of debate. Here, we used the IMPULSED approach, and show that cell radii in tumor spheroids of three different cell lines can be determined with high accuracy. In an in vivo model, however, deviations from radii determined by laser scanning microscopy were found.
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