Longitudinal assessment of glioma burden is important for evaluating treatment response and tumor progression. Delineation of tumor regions is typically performed manually but is time-consuming and subject to inter-rater and intra-rater variability. Therefore, there has been interest in developing automated approaches to calculate 1) glioma volume and 2) the product of maximum diameters of contrast-enhancing tumor (the key measure used in the Response Assessment for Neuro-Oncology (RANO) criteria). We present a fully automated pipeline for brain extraction, tumor segmentation, and RANO measurement (AutoRANO). We show the utility of this pipeline on 713 MRI scans from 54 post-operative glioblastoma patients, demonstrating capacity for tumor burden measurement.
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