Abstract #0009

The Accuracy of Hyperpolarized 129Xe Ventilation Derived from 3D Radial Gas Exchange MRI versus Multi-Slice Gradient Echo Imaging

Mu He^1,2, Ziyi Wang^2,3, Leith Rankine^2,4, Elianna A Bier^2,3, John Nouls², and Bastiaan Driehuys^2,4

¹Department of Electrical Engineering and Computer, Duke University, DURHAM, NC, United States, ²Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, DURHAM, NC, United States, ⁴Department of Medical Physics, Duke University, DURHAM, NC, United States

Both multi-slice GRE and 3D-radial acquisitions can image regional ventilation in the lungs. Here, we sought to evaluate the accuracy of the ventilation images acquired as part of a 3D-radial gas-exchange acquisition by comparing them with those acquired with a standard GRE acquisition. Linear-binning quantification was applied on both acquisitions to derive the quantitative metrics, through which we found good qualitative and modest pixel-wise agreement between the two ventilation scans. With further reconciliation of bias-field correction and threshold-setting for the 3D-radial pipeline, it could become a one-stop shop for single-breath ventilation and gas exchange imaging.

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