Abstract #5638

STimulated Echo based Mapping (STEM) of T1, T2 and Apparent Diffusion Coefficient

Yuxin Zhang^1,2, Xiaoke Wang^1,3, Valentina Taviani⁴, and Diego Hernando^1,2

¹Radiology, University of Wisconsin Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin Madison, Madison, WI, United States, ⁴Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States

This study proposed an approach for joint estimation of T1 and T2 relaxation as well as quantitative diffusion parameters. The proposed approach has been evaluated in quantitative relaxation-diffusion phantom, in-vivo brain imaging and prostate imaging. The overall T1, T2 and ADC measurements have been shown to be accurate compared to reference maps. In this feasibility study, the acquisition was over-sampled in TM-TE-b space, which limited the scan time. Future work will introduce undersampling and protocol optimization. In summary, this method has the potential to enable multi-dimensional tissue characterization in clinically feasible acquisition times.

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