Two methods for T1 mapping – 2D Look-Locker (LL) and 3D variable-flip-angle (VFA) combined with a 2-point-Dixon technique – were compared in phantom and patient measurements. LL yielded reliable results with homogeneous T1 maps of the liver, but was restricted to 3 slices. VFA yielded T1 mapping of the whole liver, but the homogeneity of T1 values across the liver was reduced which led to marked reduction of mean T1 in some patients compared with LL. The VFA variants based on in-phase and water signals showed differences in T1 for increased hepatic fat.
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