Abstract #5598

3D Magnetic Resonance Elastography of the Lungs in A Breathhold: A Reproducibility Study.

Faisal Fakhouri^1,2, Huiming Dong^1,2, and Arunark Kolipaka^1,2,3

¹Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ²Department of Radialogy, The Ohio State University - Wexner Medical Center, Columbus, OH, United States, ³Department of Internal Medicine-Division of Cardiology, The Ohio State University - Wexner Medical Center, Columbus, OH, United States

Lung stiffness changes with different diseases; in which some diseases make the lung stiffer while others make it softer. This study was performed on 15 healthy volunteers to validate the reproducibility of proposed technique and to determine a base line shear stiffness of healthy lungs at both residual volume (RV) and total lung capacity (TLC) by using magnetic resonance elasotgraphy (MRE). It was found that the actual shear stiffness of the lung at RV is 0.66±0.11 kPa and at TLC is 1.05±0.31 kPa. Also, the technique was successfully reproducible with high correlation coefficients (R²=0.879 at RV and R²=0.961 at TLC).

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