Analysis of dynamic contrast enhanced (DCE) MRI using the reference region model (RRM) requires manual identification of a reference tissue, which is typically chosen as muscle external to the tissue of interest. The current work proposes an automated technique, named the self-reference approach, for finding a suitable reference-region curve from within the tissue of interest. This approach was evaluated on in-vivo data from glioblastoma and sarcoma patients, and was found to be equally as effective as manual identification of the reference tissue in most cases, and in some cases provides substantially improved fits.
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