Abstract #5508

Evaluating the use of Oxygen-Enhanced MRI with ICA to assess the tumour oxygenation status in murine tumour models

Firas Moosvi¹, Jennifer H.E. Baker², Andrew Yung³, Piotr Kozlowski³, Andrew I. Minchinton², and Stefan Reinsberg¹

¹Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada, ³UBC 7T MRI Research Centre, University of British Columbia, Vancouver, BC, Canada

Want to assess the oxygenation status of tumours using non-invasive, contrast-agent free MRI? In this work we explore how OE-MRI can be used to extract and amplify signal from oxygen gas challenges in mouse tumours. With only dynamic T1-weighted images we can create rich oxygenation status maps that show high correlation with pimonidazole staining.

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