Abstract #5496

Dipolar relaxation time (T1D) mapping to assess myelin in vivo

Victor N. D. Carvalho^1,2, Olivier M. Girard¹, Valentin H. Prevost¹, Samira Mchinda¹, Gopal Varma³, David C. Alsop³, Pierre Thureau², and Guillaume Duhamel¹

¹Aix Marseille Univ, CNRS, CRMBM UMR 7339, Marseille, France, ²Aix Marseille Univ, CNRS, ICR UMR 7273, Marseille, France, ³Department of Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

The dipolar relaxation time (T_1D) is related to motion restricted molecules and could be used to assess myelin molecular dynamics associated with physiopathology processes. T_1D was measured with the inhomogeneous magnetization transfer (ihMT). T_1D maps were obtained from in-vivo mouse brain and from ex-vivo rat spinal cord at different temperatures. T_1D was approximately 5ms in brain and 1.8ms in muscle. T_1D in spinal cord was doubled from 26°C to 37°C, reflecting changes in molecular dynamics caused by the temperature rise. Measuring T_1D in-vivo could give information about the myelin membrane structure altered in neurological disorders.

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