Methods for quantitative measurement of myelin are of great interest for understanding brain tissue microstructure, and have potentially important implications in clinical settings for improved diagnosis and prognosis in demyelinating diseases. Quantitative Magnetization Transfer (qMT) has been proposed as a sensitive MRI technique for myelin mapping in the central nervous system. However, after an initial wave of interest, it has never found a successful translation into a clinical scenario, mostly due to its prohibitive scan time. Here we investigate solutions to promote the development of fast qMT protocols including simultaneous multi-slice EPI, and provide preliminary results in vivo.
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