Abstract #5486

On the sensitivity of T1 mapping methods to myelin

Damien Nguyen^1,2, Tobias Kober^3,4,5, and Oliver Bieri^1,2

¹Radiological Physics, University Hospital Basel, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthineers, Lausanne, Switzerland, ⁴Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

For homogeneous and isotropic probes, different MR relaxometry methods are expected to yield consistent results. For tissues, however, wide-spread T₁ and T₂ relaxation times are reported in the literature. Especially in the brain, we hypothesize that the microstructure, e.g. the presence of myelin, affects the apparent observed T₁, as assessed by different imaging sequences. As a result, apparent differences in T₁ might reflect valuable information on the underlying tissue microstructure, such as myelination.

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