A fast, multi-echo (ME) fMRI acquisition method, ISAK, is introduced by employing the classic keyhole method in a between-echo manner. ISAK acquires eight echoes within 70 ms, and the associated contrast-to-noise-ratio (CNR) improvement is up to more than 200%. The stronger blood-oxygen-level-dependent sensitivity, compared with regular ME fMRI with four echoes and standard single-echo fMRI without any acceleration, proves the benefit of trading a fraction of spatial samples in each image for more temporal echoes images in improving CNR.
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