Quantifying cerebral hemodynamics in developing children using multiple post-labeling delay pseudo-continuous arterial spin labeling

Arterial Spin Labeling (ASL) is an attractive option for studies in pediatric populations due to its ability to acquire quantitative cerebral perfusion measurements without ionizing radiation. Brain vascular dynamics in children are different from adults and rapidly changing with age. ASL sequence parameters must therefore be carefully chosen and longitudinal studies must account for normally occurring neurodevelopment. Here we present a multiple-post label delay pseudo-continuous ASL approach to quantifying cerebral blood flow, arterial transit time, and cerebral blood volume in children. We show analysis of the PLD selections with respect to ATT values and test-retest reliability of the CBF measurements.