Abstract #5434

Trajectories of brain lactate and energy metabolite concentrations do not contribute to elevated aerobic glycolysis across childhood

Helene Benveniste¹, Gerald Dienel², Zvi Jacob³, Hedok Lee¹, Rany Makaryus³, Albert Gjedde⁴, Fahmeed Hyder⁵, and Douglas L. Rothman⁵

¹Anesthesiology, Yale School of Medicine, New Haven, CT, United States, ²Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ³Anesthesiology, Stony Brook Medicine, Stony Brook, NY, United States, ⁴Panum Institute, University of Copenhagen, Copenhagen, Denmark, ⁵Department of Biomedical Engineering & Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

Lactate is produced in normal brain even when O₂ levels are ample, and high lactate production may explain aerobic glycolysis (AG) in developing brain. We evaluated steady state lactate concentrations ([Lac]) in brains of 87 children using 1HMRS while they underwent routine MRI examination. The trajectory of [Lac] in cerebral cortex across childhood was below the 0.5-0.7 mM range in normal adult brain. Thus, lactate accumulation and efflux are unlikely to underlie excessive AG in children.

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