Abstract #5427

White Matter Integrity in Adolescents with Attention Deficit Hyperactivity Disorder with Comorbid Bipolar Disorder assessed by Tract Based Spatial Statistics

Arzu Ceylan Has¹, Mahmut Mujdeci², Gokce Nur Say², Hediye Pinar Gunbey³, Nilufer Okumus⁴, Yusuf Karaer⁵, Halime Tuna Cak Esen⁵, Ozlem Yildiz Gundogdu⁴, Rahsan Gocmen⁶, and Yonca Anik⁷

¹National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, ²Department of Child and Adolescents Psychiatry, On Dokuz Mayis University, Samsun, Turkey, ³Department of Radiology, On Dokuz Mayis University, Samsun, Turkey, ⁴Department of Child and Adolescents Psychiatry, Kocaeli University, Kocaeli, Turkey, ⁵Department of Child and Adolescents Psychiatry, Hacettepe University, Ankara, Turkey, ⁶Department of Radiology, Hacettepe University, Ankara, Turkey, ⁷Department of Radiology, Kocaeli University, Kocaeli, Turkey

White matter (WM) integrity is an important factor for the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) in adolescents. In this study, we hypothesized that adolescents with attention deficit hyperactivity disorder with comorbid bipolar disorder (ADHD+BD) would yield different pattern and extent of WM abnormalities than ADHD and BD. Sixty adolescents were categorized into four groups as ADHD, BD, ADHD+BD and healthy controls. The comparative diffusion tensor imaging analyses were performed between each patient group and healthy controls. Adolescents with ADHD+BD displayed different pattern and extent of WM abnormalities than ADHD and BD revealed by tract-based spatial statistics.

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