Abstract #5423

Fetal T1 mapping using multi-inversion EPI at 3T

Borjan Gagoski^1,2, Daniel Joseph Park³, Ville Renvall^3,4, Esra Abaci-Turk^1,5, Elfar Adalsteinsson^6,7, Thomas Witzel^2,3, Lawrence L. Wald^3,8, Patricia Ellen Grant^1,5, and Jonathan Polimeni^2,3

¹Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland, ⁵Department of Newborn Medicine, Harvard Medical School, Boston, MA, United States, ⁶Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁷Harvard-MIT Health Sciences and Technology, Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁸Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

T₁ mapping of the fetal brain is hindered by substantial, frequent, and random fetal motion, making many current quantitative techniques impractical in the fetus. We have applied to the fetal brain (and adult brain for validation purposes) a recently introduced T₁ mapping technique based on EPI readout that is preceded by a non-selective inversion pulse, and where the order of the acquired slices is permuted from one inversion recovery to the next, allowing efficient, high temporal sampling of the T₁ relaxation curve. We believe that this method is capable of providing accurate T₁ maps of the fetal brain.

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