Abstract #5396

Structural and quantitative MRI to identify lesion level dependant neurodegeneration after SCI

Michela Azzarito¹, Patrick Grabher¹, Maryam Seif¹, and Patrick Freund^1,2,3

¹Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zürich, Switzerland, ²Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, UK, london, United Kingdom, ³Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, leipzig, Germany

Patients with spinal cord injury (SCI) undergo neurodegeneration affecting the spinal cord and the brain. However, the volumetric and microstructural patterns of degeneration, their relation to lesion level and clinical outcomes are uncertain. In this study, both structural and quantitative MRI approaches are used in order to identify lesion dependent neurodegeneration following SCI. It was found that lesion level drives structural changes in the spinal cord but not brain.

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