Abstract #5369

Brain axonal and myelin changes after positive airway pressure treatment in patients with obstructive sleep apnea

Ashish Kaul Sahib¹, Bhaswati Roy², Xiaopeng Song¹, Sadhana Singh¹, Luke Ehlert¹, Ravi Aysola³, Daniel Kang³, Mary Woo², and Rajesh Kumar^1,4,5,6

¹Departments of Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ³Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

Newly-diagnosed, treatment-naïve obstructive sleep apnea subjects show predominately acute tissue changes in gray and white matter, in addition to autonomic, mood, and cognitive deficits, but the extent of brain tissue recovery after PAP treatment and required minimum treatment time is unclear. We examined brain axonal and myelin changes at baseline and tissue recovery after 3 and 9 months’ positive airway pressure treatment in OSA compared to control subjects. Our findings indicate that brain structural changes found in newly-diagnosed OSA subjects can be reversible with long-term PAP treatment.

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