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Abstract #5367

Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging

Cibu Thomas1, Neda Sadeghi2, Aaron Trefler1, Joelle Sarlls3, Chris Baker1, and Carlo Pierpaoli2

1National Institute of Mental Health, Bethesda, MD, United States, 2National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States, 3National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Although diurnal fluctuations in DTI-based measures of brain tissue properties have been reported, the underlying mechanism has not been investigated. Here, we processed multi-shell diffusion data using the conventional monoexponential tensor model as well as with a dual-compartment tensor model and assessed whether, time-of-day (TOD) fluctuations in DTI measures are due to changes in the magnitude of a CSF-like water compartment, or due to changes in the diffusion properties of parenchymal water. Our results suggest that TOD effects are due to fluctuations in the magnitude of a CSF-like water compartment rather than changes in the diffusion properties of parenchymal water.

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