Abstract #5356

Different Models of Ultra-high b-Value DWI for Better Detection of Restricted Diffusion

Qiqi Tong¹, Hongjian He¹, Tianyi Qian², Yi Sun³, Ting Gong¹, and Jianhui Zhong¹

¹Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²MR Collaboration NE Asia, Siemens Healthcare, Beijing, China, ³MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Diffusion-weighted imaging with high b-value can potentially capture the restricted diffusion in tissues. With high-b-value diffusion weighting, the signal in tissue decays non-exponentially, thus the expansion of DWI signal usually be interpreted at second order or higher. However, in the ultra-high b-value (b>4k s/mm²), the cumulant expansion of higher order would fail to fit the signal. In this study, DTI, DKI, biexponential and Kärger models were used for approximating DWI signals with ultra-high b-values.

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