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Abstract #5350

Diffusion and Perfusion Analysis using Intravoxel Incoherent Motion (IVIM): A Twenty Patient Study with Osteosarcoma

Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Kedar Khare3, Raju Sharma2, Sameer Bakhshi4, and Amit Mehndiratta1,5

1Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India, 2Radiodiagnosis, All India Institure of Medical Sciences, New Delhi, New Delhi, India, 3Department of Physics, Indian Institute of Technology, Delhi, New Delhi, India, 4Department of Medical Oncology, IRCH, All India Institure of Medical Sciences, New Delhi, New Delhi, India, 5Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Quantitative analysis of Intravoxel incoherent motion (IVIM) effect of diffusion weighted imaging can assess both diffusion and perfusion component of tissue separately. To the best of our knowledge, IVIM analysis in primary bone tumors has not been reported yet and no reference for IVIM parameter values in bone tumors is available for simulation study. We estimated quantitative IVIM parameters using state-of-the-art IVIM analysis method – Bi-exponential model with adaptive Total Variation penalty function (BE+TV) in a cohort of twenty patients with Osteosarcoma that is useful for IVIM analysis in bone tumors for prognosis and can serve as standard reference for future studies.

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Abstract